In a large bowl, combine the ground beef with salt, black pepper, garlic powder, onion powder, and Worcestershire sauce. Mix well with your hands or a fork until just combined. Be careful not to overwork the meat.

Divide the mixture into equal parts, about 1/4 pound each. Shape each portion into a round patty, about ¾ inch thick, and make a slight indentation in the center.

Preheat your grill or non-stick skillet over medium-high heat.

Place the patties on the grill or skillet. Cook for about 4-5 minutes per side for medium-rare, or longer if you prefer them more well-done. Use a meat thermometer to check for doneness (internal temperature should reach at least 160°F).

Once cooked, remove the patties from heat and let them rest for a minute. Toast the burger buns on the grill if desired. Layer your toppings, and enjoy!